Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimers Disease and Related Tauopathies-Reference-Cited by-同舟云学术

Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimers Disease and Related Tauopathies

Published:2016-03-15 Issue:2 Volume:357 Page:432-450
ISSN:1521-0103
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:Journal of Pharmacology and Experimental Therapeutics

Author:

Kovalevich J.,Cornec A.-S.,Yao Y.,James M.,Crowe A.,Lee V. M.- Y.,Trojanowski J. Q.,Smith A. B.,Ballatore C.,Brunden K. R.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference52 articles.

1. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

2. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

3. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

4. Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

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