Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified-Reference-Cited by-同舟云学术

Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified

Published:2020-01-18 Issue:3 Volume:48 Page:187-197
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Breysse Daniel H.,Boone Ryan M.,Long Cameron M.,Merrill Miranda E.,Schaupp Christopher M.,White Collin C.,Kavanagh Terrance J.,Schmidt Edward E.,Merrill Gary F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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4. Comparative activity of doxorubicin and its major metabolite, doxorubicinol, on fibroblasts: A morphofunctional study

5. Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

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