Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway-Reference-Cited by-同舟云学术

Identification of Novel Metabolic Pathways of Pioglitazone in Hepatocytes: N-Glucuronidation of Thiazolidinedione Ring and Sequential Ring-Opening Pathway

Published:2010-02-25 Issue:6 Volume:38 Page:946-956
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Uchiyama Minoru,Fischer Thomas,Mueller Juergen,Oguchi Minoru,Yamamura Naotoshi,Koda Hiroko,Iwabuchi Haruo,Izumi Takashi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference32 articles.

1. Thiazolidinedione Bioactivation: A Comparison of the Bioactivation Potentials of Troglitazone, Rosiglitazone, and Pioglitazone Using Stable Isotope-Labeled Analogues and Liquid Chromatography Tandem Mass Spectrometry

2. An Improved Chemo-Enzymatic Synthesis of 1-β-O-Acyl Glucuronides: Highly Chemoselective Enzymatic Removal of Protecting Groups from Corresponding Methyl Acetyl Derivatives

3. Pioglitazone: A Review of Japanese Clinical Studies

4. METABOLIC ACTIVATION OF PIOGLITAZONE IDENTIFIED FROM RAT AND HUMAN LIVER MICROSOMES AND FRESHLY ISOLATED HEPATOCYTES

5. A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus

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