Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung

Author:

Maertens Laura A.,Upadhyaya Pramod,Hecht Stephen S.,Zimmerman Cheryl L.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference34 articles.

1. Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung

2. Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine;Belinsky;Exp Lung Res,1991

3. Dose-response relationship between O 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Belinsky;Cancer Res,1990

4. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone;Belinsky;Cancer Res,1986

5. Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver;Breyer-Pfaff;Drug Metab Dispos,2004

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