Pharmacokinetic Modeling and [123I]5-IA-85380 Single Photon Emission Computed Tomography Imaging in Baboons: Optimization of Dosing Regimen for ABT-089

Author:

Chin Chih-Liang,Carr Robert A.,Llano Daniel A.,Barret Olivier,Xu Hongyu,Batis Jeffrey,Koren Andrei O.,Seibyl John P.,Marsh Kennan C.,Tamagnan Gilles,Decker Michael W.,Day Mark,Fox Gerard B.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference40 articles.

1. Bain E Apostol G Sangal RB Robieson WZ Abi-Saab WM Saltarelli M (2009) Safety and efficacy of ABT-089, a novel α4β2 neuronal nicotinic receptor partial agonist, in the treatment of adults with attention-deficit/hyperactivity disorder, 56th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, abstract 3.3; 2009 Oct 27–Nov 1; Honolulu, Hawaii. American Academy of Child and Adolescent Psychiatry, Washington, DC.

2. Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma

3. Further studies on nicotine-induced emesis: Nicotinic mediation in area postrema

4. In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography

5. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys;Decker;J Pharmacol Exp Ther,1997

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