Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]-Reference-Cited by-同舟云学术

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Published:2009-09-09 Issue:3 Volume:331 Page:816-826
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Jobson Andrew G.,Lountos George T.,Lorenzi Philip L.,Llamas Jenny,Connelly John,Cerna David,Tropea Joseph E.,Onda Akikazu,Zoppoli Gabriele,Kondapaka Sudhir,Zhang Guangtao,Caplen Natasha J.,Cardellina John H.,Yoo Stephen S.,Monks Anne,Self Christopher,Waugh David S.,Shoemaker Robert H.,Pommier Yves

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference40 articles.

1. Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation

2. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation;Ahn;Cancer Res,2000

3. CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

4. Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles

5. The DNA Damage Sensors Ataxia-Telangiectasia Mutated Kinase and Checkpoint Kinase 2 Are Required for Hepatitis C Virus RNA Replication

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