Novel Phosphoinositide 3-Kinase δ,γ Inhibitor: Potent Anti-Inflammatory Effects and Joint Protection in Models of Rheumatoid Arthritis-Reference-Cited by-同舟云学术

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Novel Phosphoinositide 3-Kinase δ,γ Inhibitor: Potent Anti-Inflammatory Effects and Joint Protection in Models of Rheumatoid Arthritis

Published:2013-11-15 Issue:2 Volume:348 Page:271-280
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Boyle David L.,Kim Hae-Rim,Topolewski Katharyn,Bartok Beatrix,Firestein Gary S.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference49 articles.

1. Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation

2. Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

3. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus;Barber;Nat Med,2005

4. Leukocyte transmigration is modulated by chemokine-mediated PI3Kγ-dependent phosphorylation of vimentin

5. PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells

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