Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo-Reference-Cited by-同舟云学术

Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

Published:2008-01-22 Issue:4 Volume:73 Page:1122-1133
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Nguyen Thien-An,Tychopoulos Marina,Bichat Florence,Zimmermann Clothilde,Flinois Jean-Pierre,Diry Monique,Ahlberg Emelie,Delaforge Marcel,Corcos Laurent,Beaune Philippe,Dansette Patrick,André François,de Waziers Isabelle

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference39 articles.

1. Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response.

2. Regioselectivity of CYP2B6: homology modeling, molecular dynamics simulation, docking

3. Chimeras of the Human Cytochrome P450 1A Family Produced in Yeast. Accumulation in Microsomal Membranes, Enzyme Kinetics and Stability

4. Molecular dynamics with coupling to an external bath

5. Phase I Study of MetXia-P450 Gene Therapy and Oral Cyclophosphamide for Patients with Advanced Breast Cancer or Melanoma

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