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Receptor Occupancy and Brain Free Fraction

Published:2009-01-21 Issue:4 Volume:37 Page:753-760
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Watson Jeanette,Wright Sara,Lucas Adam,Clarke Kirsten L.,Viggers Jean,Cheetham Sharon,Jeffrey Phil,Porter Rod,Read Kevin D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference15 articles.

1. Nonlinear regression using spreadsheets

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

3. Considerations in the Use of Cerebrospinal Fluid Pharmacokinetics to Predict Brain Target Concentrations in the Clinical Setting

4. THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

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