In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid fromLigularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors-Reference-Cited by-同舟云学术

In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid fromLigularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors

Published:2007-07-16 Issue:10 Volume:35 Page:1832-1839
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Tang Jun,Akao Teruaki,Nakamura Norio,Wang Zheng-Tao,Takagawa Kiyoshi,Sasahara Masakiyo,Hattori Masao

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference41 articles.

1. Buhler DR, Miranda CL, Kedzierski B, and Reed RL (1990) Mechanisms for pyrrolizidine alkaloid activation and detoxification, in Biological Reactive Intermediates IV (Witmer CM, Snyder RS, Jollow DJ, Kalf GF, Kocsis JJ, and Sipes IG eds) pp 597-603. Plenum Press, New York.

2. In vivo metabolism of retrorsine and retrorsine-N-oxide

3. Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases

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