Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor-Reference-Cited by-同舟云学术

Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

Published:2015-08-27 Issue:5 Volume:88 Page:836-845
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Huang Manna,Shao Yongxian,Hou Jianying,Cui Wenjun,Liang Beibei,Huang Yingchun,Li Zhe,Wu Yinuo,Zhu Xinhai,Liu Peiqing,Wan Yiqian,Ke Hengming,Luo Hai-Bin

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference42 articles.

1. Putting chirality to work: the strategy of chiral switches

2. Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

3. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

4. The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

5. Features and development ofCoot

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