The Staurosporine-Like Compound L-753,000 (NB-506) Potentiates the Neurotrophic Effects of Neurotrophin-3 by Acting Selectively at the TrkA Receptor

Author:

Pollack Scott,Young Lisa,Bilsland James,Wilkie Neil,Ellis Semantha,Hefti Franz,Broughton Howard,Harper Sarah

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference35 articles.

1. Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506): Its potent antitumor activities in mice.;Arakawa;Cancer Res,1995

2. The Trk family of neurotrophin receptors

3. Biological roles of neurotrophins;Barde;Neurotrophic Factors: Handbook of Experimental Pharmacology,1998

4. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

5. K-252a inhibits nerve growth factor-induced Trk proto-oncogene tyrosine phosphorylation and kinase activity.;Berg;J Biol Chem,1992

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