Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmaceutical Science,Pharmacology
Reference25 articles.
1. Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey:in vitro/in vivocorrelation and the role of aldehyde oxidase
2. Species variation in hepatic aldehyde oxidase activity;Beedham;Eur J Drug Metab Pharmacokinet,1987
3. 1-Substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases
4. Substrate Specificity of Human Liver Aldehyde Oxidase toward Substituted Quinazolines and Phthalazines: A Comparison with Hepatic Enzyme from Guinea Pig, Rabbit, and Baboon
5. Bounaud P Smith C Jefferson E (2008) inventors
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