A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments-Reference-Cited by-同舟云学术

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

Published:2010-09-16 Issue:12 Volume:38 Page:2147-2156
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Gao Hongying,Deng Shibing,Obach R. Scott

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference26 articles.

1. Interpretation and Considerations on the Safety Evaluation of Human Drug Metabolites

2. Drug Metabolites in Safety Testing

3. A Regulatory Perspective on Issues and Approaches in Characterizing Human Metabolites

4. Metabolites in Safety Testing: “MIST” for the Clinical Pharmacologist

5. Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap

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