Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways-Reference-Cited by-同舟云学术

Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways

Published:2010-11-02 Issue:2 Volume:39 Page:199-207
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Zollinger Markus,Gschwind Hans-Peter,Jin Yi,Sayer Claudia,Zécri Frédéric,Hartmann Stefan

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference26 articles.

1. Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

2. Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

3. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology

4. The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

5. Fingolimod: A Novel Immunosuppressant for Multiple Sclerosis

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