Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide-Reference-Cited by-同舟云学术

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Published:2010-07-06 Issue:10 Volume:38 Page:1857-1864
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Sawamura Ryoko,Okudaira Noriko,Watanabe Kengo,Murai Takahiro,Kobayashi Yoshimasa,Tachibana Masaya,Ohnuki Takashi,Masuda Kayoko,Honma Hidehito,Kurihara Atsushi,Okazaki Osamu

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference27 articles.

1. Structure−Activity Relationships for Degradation Reaction of 1-β-O-Acyl Glucuronides: Kinetic Description and Prediction of Intrinsic Electrophilic Reactivity under Physiological Conditions

2. Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug–protein adducts

3. Acyl glucuronide reactivity in perspective: biological consequences

4. Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

5. Predictability of the covalent binding of acidic drugs in man

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