Characterization of Newcastle Disease Virus in Southeast Asia and East Asia: Fusion Protein Gene

Abstract

The aim of this study was to generate the bioinformatics analysis of the circulating NDVs in Southeast Asia, East Asia, and the vaccine virus strains through a database of isolates stored in GenBank® (National Center for Biotechnology Information, USA). The used isolates were AJ629062.1 (La Sota), AF309418.1 (B1), EF201805.1 (Mukteswar), KT445901.1 (Komarov), JX524203.1 (V4), AY935499.2 (I-2), KC987036.1 (F), KF767104.1 (Indonesia), KF767105.1 (Indonesia), KF767106.1 (Indonesia), HQ697255.1 (Indonesia), HQ697256.1 (Indonesia), HQ697261.1 (Indonesia), JX012096.2 (Malaysia), GU332646.1 (Vietnam), AF358786.1 (Taiwan), AF358788.1 (China), KT380032.1 (Republic of Korea), and KC503416.1 (Japan). As the results, this study have revealed the data of homology, pathotype, genetic distance, B cell epitope prediction, and molecular phylogenetic analysis of circulating NDVs in Southeast Asia and East Asia and vaccine virus strains. Thus, the results of this study can be used as a reference for vaccine design studies in the applications of poultry vaccine industryReceived: 28 August 2019; Accepted: 31 December 2019; Published: 11 January 2020.