Author:
Thwood Dalal A.,Elgadiym Zaynab A.,Hnaya Maren F.,Abosedra Amina
Abstract
Prevalence of extended-spectrum β-lactamases (ESBLs)- producing E. coli and K. pneumoniae has been increased globally. The study aimed to detect the prevalence of ESBL-producing E. coli and K. pneumoniae isolated from clinical specimens in Tripoli university hospital (TUH) and to evaluate their antimicrobial resistance profile. We retrospectively reviewed the recorded cultures results in the microbiology laboratory, TUH during the first half of the year 2021. 77% of E. coli and 72.5% K. pneumonia were multidrug resistant. ESBL phenotype detected in 20% of K. pneumonia and 17.5% E. coli. ESBLs were isolated more frequently from the surgical ward (32.4%). ESBLs show high resistance to beta-lactam and other antibiotics including TMP/SMZ, and aminoglycosides. Our study showed a considerably high prevalence of ESBLs positive strains of E. coli and k. pneumoniae
Reference40 articles.
1. Pitout JD, Laupland KB. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. The Lancet Infect Dis 2008; 8(3):159-66.
2. World Health Organization (WHO) Scientific Working Group. Antimicrobial resistance. Bulletin of the World Health Organization. 1983;61(3):383.
3. European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2015. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2017.
4. Ghafourian S, Sadeghifard N, Soheili S, Sekawi Z. Extended spectrum beta-lactamases: definition, classification and epidemiology. Curr Issues Mol Biol. 2015 ;17(1):11-22.
5. Riccio ME, Verschuuren T, Conzelmann N, Martak D, Meunier A, Salamanca E, et al. Household acquisition and transmission of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients. Clin Microbiol Infect. 2021; 27(9):1322-29.