Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)-Reference-Cited by-同舟云学术

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)

Published:2016-03-10 Issue:6 Volume:59 Page:2810-2819
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Majer Pavel¹,Jančařík Andrej¹,Krečmerová Marcela¹,Tichý Tomáš¹,Tenora Lukáš¹,Wozniak Krystyna²,Wu Ying²,Pommier Elie²,Ferraris Dana³,Rais Rana²⁴,Slusher Barbara S.²⁴

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic

2. Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, Maryland 21205, United States

3. Department of Chemistry, McDaniel College, Westminster, Maryland 21157, United States

4. Johns Hopkins Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, United States

Funder

National Cancer Institute

Institute of Organic Chemistry and Biochemistry AS CR, v.v.i.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00062

Reference36 articles.

1. Glutamate Carboxypeptidase II

2. Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: Implications for axon–glia signaling

3. Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber

4. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

5. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain – relation to brain concentration

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