Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K-Reference-Cited by-同舟云学术

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K

Published:2017-02-28 Issue:5 Volume:60 Page:2018-2025
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gerlits Oksana¹,Keen David A.²,Blakeley Matthew P.³^ORCID,Louis John M.⁴,Weber Irene T.⁵^ORCID,Kovalevsky Andrey⁶^ORCID

Affiliation:

1. UT/ORNL Joint Institute of Biological Sciences, University of Tennessee, Knoxville, Tennessee 37996, United States

2. ISIS Facility, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, U.K.

3. Large-Scale Structures Group, Institut Laue Langevin, 71 avenue des Martyrs, 38000 Grenoble, France

4. Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, United States

5. Departments of Chemistry and Biology, Georgia State University, Atlanta, Georgia 30302, United States

6. Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01767

Reference53 articles.

1. Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

2. HIV-I protease: Maturation, enzyme specificity, and drug resistance

3. Current and Novel Inhibitors of HIV Protease

4. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

5. Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV

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