Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors-Reference-Cited by-同舟云学术

Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors

Published:2016-08-17 Issue:16 Volume:59 Page:7544-7560
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Glatthar Ralf¹,Stojanovic Aleksandar¹,Troxler Thomas¹,Mattes Henri¹,Möbitz Henrik¹,Beerli Rene¹,Blanz Joachim¹,Gassmann Ernst¹,Drückes Peter¹,Fendrich Gabriele¹,Gutmann Sascha¹,Martiny-Baron Georg¹,Spence Fiona¹,Hornfeld Jeff¹,Peel John Edmonson¹,Sparrer Helmut¹

Affiliation:

1. Global Discovery Chemistry, ‡Analytical Sciences, §Center for Proteomic Chemistry, ∥Preclinical Safety, and ⊥Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00598

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4. ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability

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