Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria

Author:

Bhakta Sanjib1,Scalacci Nicolò23,Maitra Arundhati1,Brown Alistair K.24,Dasugari Saiprasad2,Evangelopoulos Dimitrios5,McHugh Timothy D.5,Mortazavi Parisa N.1,Twist Alexander2,Petricci Elena6,Manetti Fabrizio6,Castagnolo Daniele23

Affiliation:

1. Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.

2. Department of Applied Sciences, Northumbria University Newcastle, Ellison Place, NE1 8ST, Newcastle upon Tyne, U.K.

3. Institute of Pharmaceutical Science, King’s College London, 150 Stamford Street, London SE1 9NH, U.K.

4. School of Medicine, Pharmacy and Health, Durham University, Queen’s Campus, Stockton-on-Tees, TS17 6BH, U.K.

5. Centre for Clinical Microbiology, University College London, London, NW3 2PF U.K.

6. Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via Aldo Moro 2, I-53100 Siena, Italy

Funder

Medical Research Council

Royal Society of Chemistry

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference36 articles.

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