Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design-Reference-Cited by-同舟云学术

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Published:2016-04-08 Issue:8 Volume:59 Page:3935-3952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yokokawa Fumiaki¹,Nilar Shahul¹,Noble Christian G.¹,Lim Siew Pheng¹,Rao Ranga¹,Tania Stefani¹,Wang Gang¹,Lee Gladys¹,Hunziker Jürg¹,Karuna Ratna¹,Manjunatha Ujjini¹,Shi Pei-Yong¹²,Smith Paul W.¹

Affiliation:

1. Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore

2. Department of Biochemistry & Molecular Biology, Department of Phamarcology & Toxicology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00143

Reference29 articles.

1. The pathogenesis of dengue

2. The global distribution and burden of dengue

3. Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

4. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection

5. The dengue virus NS5 protein as a target for drug discovery

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