Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis-Reference-Cited by-同舟云学术

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

Published:2017-04-26 Issue:9 Volume:60 Page:3672-3683
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Velcicky Juraj¹^ORCID,Miltz Wolfgang¹,Oberhauser Berndt¹,Orain David¹,Vaupel Andrea¹,Weigand Klaus¹,Dawson King Janet¹,Littlewood-Evans Amanda¹,Nash Mark¹,Feifel Roland¹,Loetscher Pius¹

Affiliation:

1. Global Discovery Chemistry, ‡Autoimmunity Transplantation Inflammation, §Musculoskeletal, ∥Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01703

Reference37 articles.

1. Proton-sensing G-protein-coupled receptors

2. Receptors for Protons or Lipid Messengers or Both?

3. Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor

4. Emerging roles for the pH-sensing G protein-coupled receptors in response to acidotic stress

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