Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Author:
Affiliation:
1. Celgene Corporation, 10300 Campus Point Drive, Suite 100, San Diego, California 92121, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01911
Reference25 articles.
1. Identification of a Primary Target of Thalidomide Teratogenicity
2. Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
3. The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
4. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
5. Structural insights into eRF3 and stop codon recognition by eRF1
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