Investigation of the Structure–Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons-Reference-Cited by-同舟云学术

Investigation of the Structure–Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons

Published:2016-04-12 Issue:8 Volume:59 Page:3840-3853
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Beck Daniel E.¹,Reddy P. V. Narasimha¹,Lv Wei¹,Abdelmalak Monica²,Tender Gabrielle S.²,Lopez Sophia²,Agama Keli²,Marchand Christophe²,Pommier Yves²,Cushman Mark¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States

2. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00003

Reference51 articles.

1. A Model for the Mechanism of Human Topoisomerase I

2. Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

3. Topoisomerase I inhibitors: camptothecins and beyond

4. Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

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