Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship-Reference-Cited by-同舟云学术

Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship

Published:2016-12-13 Issue:24 Volume:59 Page:11171-11181
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cook James¹^ORCID,Zusi F. Christopher¹,McDonald Ivar M.¹,King Dalton¹,Hill Matthew D.¹,Iwuagwu Christiana¹,Mate Robert A.¹,Fang Haiquan¹,Zhao Rulin¹,Wang Bei¹,Cutrone Jingfang¹,Ma Baoqing¹,Gao Qi¹,Knox Ronald J.¹,Matchett Michele¹,Gallagher Lizbeth¹,Ferrante Meredith¹,Post-Munson Debra¹,Molski Thaddeus¹,Easton Amy¹,Miller Regina¹,Jones Kelli¹,Digavalli Siva¹,Healy Francine¹,Lentz Kimberley¹,Benitex Yulia¹,Clarke Wendy¹,Natale Joanne¹,Siuciak Judith A.¹,Lodge Nicholas¹,Zaczek Robert¹,Denton Rex¹,Morgan Daniel¹,Bristow Linda J.¹,Macor John E.¹,Olson Richard E.¹

Affiliation:

1. Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01506

Reference54 articles.

1. A Systematic Review of Mortality in Schizophrenia

2. Schizophrenia as a Complex Trait

3. Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

4. Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia

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