Fluorinated Chaperone−β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease

Author:

García-Moreno M. Isabel1,de la Mata Mario2,Sánchez-Fernández Elena M.1,Benito Juan M.3,Díaz-Quintana Antonio3,Fustero Santos45ORCID,Nanba Eiji6,Higaki Katsumi6,Sánchez-Alcázar José A.2,García Fernández José M.3ORCID,Ortiz Mellet Carmen1

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, c/Profesor García González 1, 41011 Sevilla, Spain

2. Centro Andaluz de Biología del Desarrollo (CABD), CSIC, Universidad Pablo de Olavide, and Centro de Investigación Biomédica en Red, Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Carretera de Utrera Km 1, 41013 Sevilla, Spain

3. Instituto de Investigaciones Químicas (IIQ), CSIC, and Universidad de Sevilla, Avda. Américo Vespucio 49, E-41092 Sevilla, Spain

4. Departamento de Química Orgánica, Universidad de Valencia, 46100 Burjassot, Spain

5. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain

6. Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan

Funder

Generalitat Valenciana

Takeda Science Foundation

Ministry of Education, Culture, Sports, Science and Technology

Fundaci?n Ram?n Areces

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Directorate-General for Research and Innovation

Ministerio de Sanidad, Servicios Sociales e Igualdad

Ministry of Health, Labour and Welfare

Junta de Andaluc?a

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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