Substituent Effects on Drug–Receptor H-bond Interactions: Correlations Useful for the Design of Kinase Inhibitors-Reference-Cited by-同舟云学术

Substituent Effects on Drug–Receptor H-bond Interactions: Correlations Useful for the Design of Kinase Inhibitors

Published:2016-11-22 Issue:23 Volume:59 Page:10629-10641
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lawhorn Brian G.¹,Philp Joanne¹,Graves Alan P.¹,Holt Dennis A.¹,Gatto Gregory J.¹,Kallander Lara S.¹

Affiliation:

1. Heart Failure Discovery Performance Unit and ‡Platform Technology and Sciences, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01342

Reference46 articles.

1. Troponin I-Interacting Protein Kinase

2. Inhibition of the Cardiomyocyte-Specific Troponin I–Interacting Kinase Limits Oxidative Stress, Injury, and Adverse Remodeling due to Ischemic Heart Disease

3. Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction

4. Tnni3k Modifies Disease Progression in Murine Models of Cardiomyopathy

5. Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

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