Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation-Reference-Cited by-同舟云学术

Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation

Published:2017-01-17 Issue:2 Volume:60 Page:681-694
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Basu Sujay¹^ORCID,Barawkar Dinesh A.¹,Thorat Sachin¹,Shejul Yogesh D.¹,Patel Meena¹,Naykodi Minakshi¹,Jain Vaibhav¹,Salve Yogesh¹,Prasad Vandna¹,Chaudhary Sumit¹,Ghosh Indraneel¹,Bhat Ganesh¹,Quraishi Azfar¹,Patil Harish¹,Ansari Shariq¹,Menon Suraj¹,Unadkat Vishal¹,Thakare Rhishikesh¹,Seervi Madhav S.¹,Meru Ashwinkumar V.¹,De Siddhartha¹,Bhamidipati Ravi K.¹,Rouduri Sreekanth R.¹,Palle Venkata P.¹,Chug Anita¹,Mookhtiar Kasim A.¹

Affiliation:

1. Drug Discovery Facility, Advinus Therapeutics Ltd., Quantum Towers, Plot-9, Phase-I, Rajiv Gandhi Infotech Park, Hinjawadi, Pune 411 057, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01584

Reference46 articles.

1. Ligand-Based Homology Modeling as Attractive Tool to Inspect GPCR Structural Plasticity

2. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells11Abbreviations: cAMP, cyclic adenosine 3′,5′-monophosphate; CHO, Chinese hamster ovary; NBMPR, nitrobenzylthioinosine; and NECA, 5′-N-ethyl carboxamido adenosine.

3. Adenosine receptor signaling in vitro and in vivo

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