Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)-Reference-Cited by-同舟云学术

Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)

Published:2016-08-26 Issue:17 Volume:59 Page:7915-7935
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Lucca George V.¹,Shi Qing¹,Liu Qingjie¹,Batt Douglas G.¹,Beaudoin Bertrand Myra¹,Rampulla Rick¹,Mathur Arvind¹,Discenza Lorell¹,D’Arienzo Celia¹,Dai Jun¹,Obermeier Mary¹,Vickery Rodney¹,Zhang Yingru¹,Yang Zheng¹,Marathe Punit¹,Tebben Andrew J.¹,Muckelbauer Jodi K.¹,Chang ChiehYing J.¹,Zhang Huiping¹,Gillooly Kathleen¹,Taylor Tracy¹,Pattoli Mark A.¹,Skala Stacey¹,Kukral Daniel W.¹,McIntyre Kim W.¹,Salter-Cid Luisa¹,Fura Aberra¹,Burke James R.¹,Barrish Joel C.¹,Carter Percy H.¹,Tino Joseph A.¹

Affiliation:

1. Immunosciences Discovery Chemistry, ‡Immunoscience Discovery Biology, §Molecular Structure and Design, Molecular Discovery Technologies, ∥Metabolism and Pharmacokinetic Department, Pharmaceutical Candidate Optimization, and ⊥ECTR/CTTO Imaging Department, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00722

Reference45 articles.

1. Pocketome of Human Kinases: Prioritizing the ATP Binding Sites of (Yet) Untapped Protein Kinases for Drug Discovery

2. Targeting cancer with kinase inhibitors

3. Quantitative Proteomics of Kinase Inhibitor Targets and Mechanisms

4. Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

5. Signalling of Bruton's Tyrosine Kinase, Btk

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