Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase-Reference-Cited by-同舟云学术

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

Published:2016-07-20 Issue:15 Volume:59 Page:7299-7304
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Concha Nestor¹,Huang Jianzhong¹,Bai Xiaopeng²,Benowitz Andrew¹,Brady Pat¹,Grady LaShadric C.²,Kryn Luz Helena³,Holmes David¹,Ingraham Karen¹,Jin Qi¹,Pothier Kaushansky Laura²,McCloskey Lynn¹,Messer Jeffrey A.²,O’Keefe Heather²,Patel Amish²,Satz Alexander L.²,Sinnamon Robert H.¹,Schneck Jessica¹,Skinner Steve R.²,Summerfield Jennifer²,Taylor Amy¹,Taylor J. David¹,Evindar Ghotas²,Stavenger Robert A.¹

Affiliation:

1. GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States

2. GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, United States

3. GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27009, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00746

Reference29 articles.

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4. Huang, J.; Jiang, X.; Pearson, S. C.; Traini, C. M.; McDevitt, D.Use of temperature-sensitive (ts) lethal mutants in the functional analysis of the Pseudomonas aeruginosa genome. Presented at the 98th General Meeting of the American Society for Microbiology, Atlanta, Georgia, May 17–21, 1998; H59.

5. The Escherichia coli Homologue of Yeast Rer2, a Key Enzyme of Dolichol Synthesis, Is Essential for Carrier Lipid Formation in Bacterial Cell Wall Synthesis

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