Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase-Reference-Cited by-同舟云学术

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Published:2016-05-04 Issue:10 Volume:59 Page:4697-4710
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fraser Craig,Dawson John C.,Dowling Reece,Houston Douglas R.¹,Weiss Jason T.,Munro Alison F.,Muir Morwenna,Harrington Lea²,Webster Scott P.³,Frame Margaret C.,Brunton Valerie G.,Patton E. Elizabeth,Carragher Neil O.,Unciti-Broceta Asier

Affiliation:

1. Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom

2. Faculty of Medicine, University of Montreal, Institute for Research in Immunology and Cancer, Chemin de Polytechnique, Montreal, Quebec H3T 1J4, Canada

3. University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom

Funder

Medical Research Council

European Research Council

Research Councils UK

Wellcome Trust

Edinburgh BioQuarter

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00065