Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines-Reference-Cited by-同舟云学术

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

Published:2017-02-14 Issue:5 Volume:60 Page:1746-1767
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Coxon Christopher R.¹,Anscombe Elizabeth²,Harnor Suzannah J.¹^ORCID,Martin Mathew P.³,Carbain Benoit¹,Golding Bernard T.¹,Hardcastle Ian R.¹,Harlow Lisa K.¹,Korolchuk Svitlana³,Matheson Christopher J.¹,Newell David R.³,Noble Martin E. M.²,Sivaprakasam Mangaleswaran¹,Tudhope Susan J.³,Turner David M.¹,Wang Lan Z.³,Wedge Stephen R.³,Wong Christopher¹,Griffin Roger J.¹,Endicott Jane A.²,Cano Céline¹^ORCID

Affiliation:

1. Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, U.K.

3. Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University Medical School, Paul O’Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, U.K.

Funder

Medical Research Council

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01254

Reference57 articles.

1. Cdks, cyclins and CKIs: roles beyond cell cycle regulation

2. Cyclin-dependent kinases