Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity-Reference-Cited by-同舟云学术

Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity

Published:2016-09-19 Issue:19 Volume:59 Page:9140-9149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fuggetta Maria Pia¹,De Mico Antonella²,Cottarelli Andrea¹,Morelli Franco³,Zonfrillo Manuela¹,Ulgheri Fausta⁴,Peluso Paola⁴,Mannu Alberto⁴,Deligia Francesco⁴,Marchetti Mauro⁴,Roviello Giovanni⁵,Reyes Romero Atilio⁶,Dömling Alexander⁶,Spanu Pietro⁴

Affiliation:

1. Istituto di Farmacologia Traslazionale, Consiglio Nazionale delle Ricerche, Via Fosso del Cavaliere, 00133 Roma, Italy

2. Istituto di Biologia e Patologia Molecolare, Consiglio Nazionale delle Ricerche, Piazzale Aldo Moro 5, 00185 Roma, Italy

3. Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy

4. Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Trav. La Crucca 3, 07100 Sassari, Italy

5. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, 80134 Naples, Italy

6. Department of Drug Design, School of Pharmacy, University of Groningen, Antonius Deusinglaan 1 Postbus 196, 9700 AD, Groningen, The Netherlands

Funder

Fase 1 srl, Regione Autonoma della Sardegna

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01046

Reference40 articles.

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2. Nonanomeric Spiroketals in Natural Products: Structures, Sources, and Synthetic Strategies

3. Antineoplastic agents. 257. Isolation and structure of spongistatin 1

4. Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. that Inhibits HIV-1 Integrase

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