Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo-Reference-Cited by-同舟云学术

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo

Published:2017-03-13 Issue:6 Volume:60 Page:2526-2551
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Soeberdt Michael¹^ORCID,Molenveld Peter²,Storcken Roy P. M.²,Bouzanne des Mazery Renaud²,Sterk Geert Jan²,Autar Reshma²,Bolster Marjon G.²,Wagner Clemens²,Aerts Sebastianus N. H.²,van Holst Frank R.²,Wegert Anita²,Tangherlini Giovanni³⁴,Frehland Bastian³,Schepmann Dirk³⁴,Metze Dieter⁵,Lotts Tobias⁵⁶,Knie Ulrich¹,Lin Kun-Yuan⁷,Huang Tai-Yu⁷,Lai Chih-Ching⁷,Ständer Sonja⁵⁶,Wünsch Bernhard³⁴,Abels Christoph¹

Affiliation:

1. Dr. August Wolff GmbH & Co. KG Arzneimittel, Sudbrackstraße 56, D-33611 Bielefeld, Germany

2. Mercachem, Kerkenbos 1013, NL-6546 BB Nijmegen, The Netherlands

3. Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Correnstraße 48, D-48149 Münster, Germany

4. Cells-in-Motion Cluster of Excellence (EXC 1003−CiM), Universität Münster, D-48149 Münster, Germany

5. Klinik für Hautkrankheiten, Universitätsklinikium Münster, Von-Esmarch-Straße 58, D-48149 Münster, Germany

6. Kompetenzzentrum chronischer Pruritus (KCP), Universitätsklinikium Münster, Von-Esmarch-Straße 58, D-48149 Münster, Germany

7. Eurofins Panlabs Taiwan, Ltd., 158 Li-Teh Road, Peitou, Taipei 11259, Taiwan

Funder

Deutsche Forschungsgemeinschaft

Dr. August Wolff GmbH & Co. KG

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01868

Reference79 articles.

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4. Kappa opioids and the modulation of pain

5. ClinicalTrials.gov. Identifier: NCT01100684.https://clinicaltrials.gov/(accessed on February 3, 2017) .

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