Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

Author:

Cocco Mattia1,Pellegrini Carolina23,Martínez-Banaclocha Helios4,Giorgis Marta1,Marini Elisabetta1,Costale Annalisa1,Miglio Gianluca1,Fornai Matteo2,Antonioli Luca2,López-Castejón Gloria3,Tapia-Abellán Ana4,Angosto Diego4,Hafner-Bratkovič Iva5,Regazzoni Luca6,Blandizzi Corrado2,Pelegrín Pablo4,Bertinaria Massimo1ORCID

Affiliation:

1. Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy

2. Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy

3. Faculty of Biology, Medicine and Health, The University of Manchester, R4.004 AV Hill Building, Oxford Road, Manchester, U.K.

4. Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital “Virgen de la Arrixaca”, University of Murcia, Carretera Buenavista s/n, 30120, El Palmar, Murcia, Spain

5. Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia

6. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy

Funder

Università degli Studi di Torino

European Regional Development Fund

Ministerio de Economía y Competitividad

European Cooperation in Science and Technology

Instituto de Salud Carlos III

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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