Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism-Reference-Cited by-同舟云学术

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism

Published:2017-03-16 Issue:7 Volume:60 Page:2890-2907
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonifazi Alessandro¹,Yano Hideaki¹,Ellenberger Michael P.¹,Muller Ludovic²,Kumar Vivek¹,Zou Mu-Fa¹,Cai Ning Sheng¹,Guerrero Adrian M.¹,Woods Amina S.²,Shi Lei¹,Newman Amy Hauck¹^ORCID

Affiliation:

1. Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

2. Structural Biology Unit, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

Funder

Japan Society for the Promotion of Science

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01875

Reference61 articles.

1. The Physiology, Signaling, and Pharmacology of Dopamine Receptors

2. GPCR functional selectivity has therapeutic impact