Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors-Reference-Cited by-同舟云学术

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

Published:2016-11-14 Issue:22 Volume:59 Page:10299-10314
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Granchi Carlotta¹,Rizzolio Flavio²,Palazzolo Stefano²³,Carmignani Sara¹,Macchia Marco¹,Saccomanni Giuseppe¹,Manera Clementina¹,Martinelli Adriano¹,Minutolo Filippo¹,Tuccinardi Tiziano¹

Affiliation:

1. Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

2. Division of Experimental and Clinical Pharmacology, Department of Molecular Biology and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, IRCCS, 33081 Aviano, Pordenone, Italy

3. Graduate School in Nanotechnology, University of Trieste, 34127 Trieste, Italy

Funder

Università di Pisa

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01459

Reference38 articles.

1. The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2. The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation