Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease

Published:2017-02-10 Issue:4 Volume:60 Page:1272-1291
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rombouts Frederik J. R.¹^ORCID,Andrés José-Ignacio²,Ariza Manuela¹,Alonso José Manuel²,Austin Nigel³,Bottelbergs Astrid²,Chen Lu⁴,Chupakhin Vladimir³,Cleiren Erna³,Fierens Katleen³,Fontana Alberto²,Langlois Xavier⁵,Leenaerts Joseph E.¹,Mariën Jonas⁵,Martínez Lamenca Carolina¹,Salter Rhys⁴,Schmidt Mark E.⁶,Te Riele Paula⁵,Wintmolders Cindy⁵,Trabanco Andrés A.⁷^ORCID,Zhang Wei⁸,Macdonald Gregor¹,Moechars Dieder⁵

Affiliation:

1. Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium

2. Discovery Sciences, Janssen Research & Development, Janssen-Cilag S. A., C/Jarama 75A, 45007 Toledo, Spain

3. Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium

4. Isotope Chemistry and Biotransformation, Janssen Research & Development, Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States

5. Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium

6. Neuroscience Experimental Medicine, Janssen Early Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium

7. Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S. A., C/Jarama 75A, 45007 Toledo, Spain

8. Neuroscience Biomarker Research, Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121, United States

Funder

Agentschap Innoveren en Ondernemen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01173

Reference72 articles.

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4. Strategies for Improving the Postmortem Neuropathological Diagnosis of Alzheimer’s Disease

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