Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

Published:2017-02-13 Issue:4 Volume:60 Page:1292-1308
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shan Chan¹²,Yan Jin-Wu¹³,Wang Yu-Qing¹,Che Tong¹,Huang Zhou-Li¹,Chen Ai-Chun¹,Yao Pei-Fen¹,Tan Jia-Heng¹,Li Ding¹,Ou Tian-Miao¹^ORCID,Gu Lian-Quan¹,Huang Zhi-Shu¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China

2. Institute for Translation Medicine, Qingdao University, Shandong 266021, People’s Republic of China

3. School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, People’s Republic of China

Funder

National Natural Science Foundation of China

Guangdong Provincial Key Laboratory of Construction Foundation, Sun Yat-sen University

Foundation for Distinguished Young Talents in Higher Education of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01218

Reference31 articles.

1. Deconstructing Myc: Figure 1.

2. c-MYC: more than just a matter of life and death

3. c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

4. MYC oncogenes and human neoplastic disease

5. Myc pathways provoking cell suicide and cancer

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