Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)-Reference-Cited by-同舟云学术

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Published:2016-09-19 Issue:19 Volume:59 Page:8924-8940
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heck Michael C.¹,Wagner Carl E.¹,Shahani Pritika H.¹,MacNeill Mairi¹,Grozic Aleksandra¹,Darwaiz Tamana¹,Shimabuku Micah¹,Deans David G.¹,Robinson Nathan M.¹,Salama Samer H.¹,Ziller Joseph W.²,Ma Ning³,van der Vaart Arjan³,Marshall Pamela A.¹,Jurutka Peter W.¹

Affiliation:

1. School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences, Arizona State University, 4701 West Thunderbird Road, Glendale, Arizona 85306, United States

2. Department of Chemistry, University of California, Irvine, 576 Rowland Hall, Irvine, California 92697, United States

3. Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620, United States

Funder

National Cancer Institute

Edward N. and Della L. Thome Memorial Foundation

Arizona State University Foundation for A New American University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00812