Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy-Reference-Cited by-同舟云学术

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Published:2016-08-20 Issue:17 Volume:59 Page:8068-8081
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cameron Kimberly O.¹²,Kung Daniel W.¹²,Kalgutkar Amit S.¹²,Kurumbail Ravi G.¹²,Miller Russell¹²,Salatto Christopher T.¹²,Ward Jessica¹²,Withka Jane M.¹²,Bhattacharya Samit K.¹²,Boehm Markus¹²,Borzilleri Kris A.¹²,Brown Janice A.¹²,Calabrese Matthew¹²,Caspers Nicole L.¹²,Cokorinos Emily¹²,Conn Edward L.¹²,Dowling Matthew S.¹²,Edmonds David J.¹²,Eng Heather¹²,Fernando Dilinie P.¹²,Frisbie Richard¹²,Hepworth David¹²,Landro James¹²,Mao Yuxia¹²,Rajamohan Francis¹²,Reyes Allan R.¹²,Rose Colin R.¹²,Ryder Tim¹²,Shavnya Andre¹²,Smith Aaron C.¹²,Tu Meihua¹²,Wolford Angela C.¹²,Xiao Jun¹²

Affiliation:

1. Cardiovascular, Metabolic and Endocrine Diseases Medicinal Chemistry, ‡Cardiovascular, Metabolic and Endocrine Diseases Research Unit, and §Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

2. Cardiovascular, Metabolic and Endocrine Diseases Medicinal Chemistry, ⊥Cardiovascular, Metabolic and Endocrine Diseases Research Unit, #Worldwide Medicinal Chemistry, ∇Pharmacokinetics, Dynamics and Metabolism, ○Pharmaceutical Sciences, Pfizer Worldwide Research & Development, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00866

Reference38 articles.

1. Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies

2. Pathophysiology of the Diabetic Kidney

3. New loci associated with kidney function and chronic kidney disease

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