Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

Author:

Myrianthopoulos Vassilios1,Gaboriaud-Kolar Nicolas1,Tallant Cynthia23,Hall Michelle-Lynn4,Grigoriou Stylianos1,Brownlee Peter Moore5,Fedorov Oleg23,Rogers Catherine23,Heidenreich David6,Wanior Marek6,Drosos Nikolaos1,Mexia Nikitia1,Savitsky Pavel23,Bagratuni Tina7,Kastritis Efstathios7,Terpos Evangelos7,Filippakopoulos Panagis23,Müller Susanne236,Skaltsounis Alexios-Leandros1,Downs Jessica Ann5,Knapp Stefan236,Mikros Emmanuel1

Affiliation:

1. Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece

2. Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, U.K.

3. Nuffield Department of Clinical Medicine, Target Discovery Institute (TDI), University of Oxford, Roosevelt Drive, Oxford OX3 7BN, U.K.

4. Schrödinger Inc., 222 Third Street, Cambridge, Massachusetts 02139, United States

5. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton BN1 9RQ, U.K.

6. Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany

7. Department of Clinical Therapeutics, School of Medicine, University of Athens, Mikras Asias 75, GR-11527 Athens, Greece

Funder

Else Kröner-Fresenius-Stiftung

Wellcome Trust

European Cooperation in Science and Technology

Seventh Framework Programme

Structural Genomics Consortium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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