Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists

Author:

Kim Jina1,Woo Seo Yeon1,Im Chun Young1,Yoo Eun Kyung2,Lee Seungmi2,Kim Hyo-Ji1,Hwang Hee-Jong1,Cho Joong-heui1,Lee Won Seok1,Yoon Heeseok1,Kim Shinae1,Kwon Oh-bin1,Hwang Hayoung1,Kim Kyung-Hee1,Jeon Jae-Han23,Singh Thoudam Debraj4,Kim Sang Wook5,Hwang Sung Yeoun5,Choi Hueng-Sik6,Lee In-Kyu23,Kim Seong Heon1,Jeon Yong Hyun24,Chin Jungwook1,Cho Sung Jin12

Affiliation:

1. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea

2. Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Korea

3. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea

4. Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea

5. Korea Bio-Medical Science Institute, Seoul 06106, Republic of Korea

6. National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea

Funder

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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