Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity-Reference-Cited by-同舟云学术

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Published:2016-05-21 Issue:11 Volume:59 Page:5416-5431
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kokkonda Sreekanth¹,Deng Xiaoyi,White Karen L.²,Coteron Jose M.³,Marco Maria³,de las Heras Laura³,White John¹,El Mazouni Farah,Tomchick Diana R.,Manjalanagara Krishne⁴,Rudra Kakali Rani⁴,Chen Gong²,Morizzi Julia²,Ryan Eileen²,Kaminsky Werner¹,Leroy Didier⁵,Martínez-Martínez María Santos³,Jimenez-Diaz Maria Belen³,Bazaga Santiago Ferrer³,Angulo-Barturen Iñigo³,Waterson David⁵,Burrows Jeremy N.⁵,Matthews Dave⁵,Charman Susan A.²,Phillips Margaret A.,Rathod Pradipsinh K.¹

Affiliation:

1. Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States

2. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia

3. GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain

4. Syngene International Ltd., Bangalore 560 099, India

5. Medicines for Malaria Venture, 1215 Geneva, Switzerland

Funder

Welch Foundation

National Institute of Allergy and Infectious Diseases

Medicines for Malaria Venture

Publisher

American Chemical Society (ACS)