Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein–Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein–Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase

Published:2016-06-08 Issue:12 Volume:59 Page:5799-5809
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harjani Jitendra R.¹,Yap Beow Keat¹,Leung Eleanor W. W.¹,Lucke Andrew¹,Nicholson Sandra E.²³,Scanlon Martin J.¹,Chalmers David K.¹,Thompson Philip E.¹,Norton Raymond S.¹,Baell Jonathan B.¹

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

2. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia

3. The Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Universiti Sains Malaysia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00386

Reference41 articles.

1. The SPRY domain–containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

2. Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

3. A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent

4. ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine

5. Synthesis and biological evaluation of nonpeptide mimetics of ω-conotoxin GVIA

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