Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors-Reference-Cited by-同舟云学术

Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors

Published:2016-06-09 Issue:12 Volume:59 Page:5810-5822
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wiley Michael R.¹,Durham Timothy B.¹,Adams Lisa A.¹,Chambers Mark G.¹,Lin Chaohua¹,Liu Chin¹,Marimuthu Jothirajah¹,Mitchell Peter G.¹,Mudra Daniel R.¹,Swearingen Craig A.¹,Toth James L.¹,Weller Jennifer M.¹,Thirunavukkarasu Kannan¹

Affiliation:

1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00398

Reference27 articles.

1. Target Engagement in Lead Generation

2. Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

3. Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry