Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1

Published:2016-09-09 Issue:18 Volume:59 Page:8473-8494
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cioffi Christopher L.¹,Liu Shuang¹,Wolf Mark A.¹,Guzzo Peter R.¹,Sadalapure Kashinath²,Parthasarathy Visweswaran²,Loong David T. J.²,Maeng Jun-Ho²,Carulli Edmund²,Fang Xiao²,Karunakaran Kalesh²,Matta Lakshman²,Choo Sok Hui²,Panduga Shailijia²,Buckle Ronald N.¹,Davis Randall N.¹,Sakwa Samuel A.¹,Gupta Priya²,Sargent Bruce J.¹,Moore Nicholas A.¹,Luche Michele M.³,Carr Grant J.³,Khmelnitsky Yuri L.⁴,Ismail Jiffry⁴,Chung Mark²,Bai Mei²,Leong Wei Yee²,Sachdev Nidhi²,Swaminathan Srividya²,Mhyre Andrew J.³

Affiliation:

1. Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, New York 12144, United States

2. Discovery Research and Development Chemistry, Singapore Research Center, AMRI, 61 Science Park Road, Science Park III, 117525, Singapore

3. Bothell Research Center, AMRI, 22215 26th Ave SE, Bothell, Washington 98021-4425, United States

4. Drug Metabolism and Pharmacokinetics, AMRI, East Campus, 17 University Place, Rensselaer, New York 12144, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00914

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1. Ligand-gated ion channels in the brain: The amino acid receptor superfamily

2. NMDA Receptor Regulation by D-serine: New Findings and Perspectives

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