Determination of in Vitro and in Silico Indexes for the Modeling of Blood–Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography-Reference-Cited by-同舟云学术

Determination of in Vitro and in Silico Indexes for the Modeling of Blood–Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography

Published:2017-04-27 Issue:9 Volume:60 Page:3739-3754
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Russo Giacomo¹²,Grumetto Lucia²,Szucs Roman³,Barbato Francesco²,Lynen Frederic¹^ORCID

Affiliation:

1. Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Gent, Belgium

2. Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano, 49, I-80131 Naples, Italy

3. Pfizer Global R&D, Sandwich CT13 9NJ, Kent, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01811

Reference42 articles.

1. An analysis of the attrition of drug candidates from four major pharmaceutical companies

2. Can the pharmaceutical industry reduce attrition rates?

3. Drug transport across the blood-brain barrier

4. The dynamic blood-brain barrier

5. How to measure drug transport across the blood-brain barrier

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